Publications

LIST OF PUBLICATIONS

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Pavlova NN and Thompson CB. Oncogenic Control of Cancer Metabolism. Cold Spring Harbor Perspectives in Medicine. 2024, Apr 2. doi: 10.1101/cshperspect.a041531


Bandyopadhyay U, Todorova P, Pavlova NN, Tada Y, Thompson CB, Finley LWS, Overholtzer M. Leucine retention in lysosomes is regulated by starvation. PNAS. 2022, Feb 8; 119(6):e2114912119. PMID: 35105808.


Pavlova NN, Zhu J, Thompson CB. The hallmarks of cancer metabolism: Still emerging. Cell Metab. 2022, 34(3), 355-377. PMID: 35123658.


Ranea-Robles P, Pavlova NN, Bender A, Stauffer B, Yu C, Thompson CB, Argmann C, Puchowicz M, Houten SM. A mitochondrial long-chain fatty acid oxidation defect leads to uncharged tRNA accumulation and activation of the integrated stress response in the mouse heart. Cardiovascular Research. 2022, cvac050.


Schwörer S, Pavlova NN, Cimino FV, King  B, Cai X, Sizemore GM, Thompson CB. Fibroblast pyruvate carboxylase is required for collagen production in the tumor microenvironment. Nat Metab. 2021, 3: 1484–1499. PMID: 34764457.


Pavlova NN, King B, Josselsohn RH, Violante S, Macera V, Vardhana SA, Cross JR, Thompson CB. Translation in amino acid-poor environments is limited by tRNAGln charging. Elife. 2020 Dec 8; 9:e62307. PMID: 33289483.


Jiang J, Srivastava S, Seim G, Pavlova NN, King B, Zou L, Zhang C, Zhong M, Feng H, Kapur R, Wek RC, Fan J, Zhang J. Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. J Biol Chem. 2019 Dec 6; 294(49):18674-18684. PMID: 31659118.


Jiang J, Pavlova NN, Zhang J. Asparagine, a critical limiting metabolite during glutamine starvation. Molecular & Cellular Oncology, 5:3, Mol Cell Oncol. 2018 Apr 11; 5(3):e1441633. PMID: 30250896.


Pavlova NN, Hui S, Ghergurovich JM, Fan J, Intlekofer AM, White RM, Rabinowitz JD, Thompson CB, Zhang J. As extracellular glutamine levels decline, asparagine becomes an essential amino acid. Cell Metab. 2018 Feb 6; 27(2):428-438.e5. PMID: 29337136.


Pavlova NN and Thompson CB. Cancer Metabolism, in: Bast, R.C., Croce, C.M., Hait, W.N., Cancer Medicine 9. 9th ed.; Wiley-Blackwell, 2017.

 

Zhang J, Pavlova NN and Thompson CB. Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine. EMBO J. 2017 May 15; 36(10):1302-1315. PMID: 28420743.


Pavlova NN and Thompson CB. The Emerging Hallmarks of Cancer Metabolism. Cell Metab. 2016, 23(1), 27-47. PMID: 26771115.


12. Palm W, Park Y, Wright K, Pavlova NN, Tuveson DA, Thompson CB. The utilization of extracellular proteins as nutrients is suppressed by mTORC1. Cell. 2015, 162(2), 259-70. PMID: 26144316.


Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ. A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife. 2013 Apr 30; 2:e00358. PMID: 23682311.


Solimini NL, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJ. STOP gene Phactr4 is a tumor suppressor. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E407-14. PMID: 23319639.


Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Nat Biotechnol. 2013 Apr 31(4):331-4. PMID: 23503679.


Larman HB, Jing Xu G, Pavlova NN, Elledge SJ. Construction of a rationally designed antibody platform for sequencing-assisted selection. Proc Natl Acad Sci U S A. 2012 Nov 6; 109(45):18523-8. PMID: 23064642.


Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 2011. Mar 4; 144(5): 703-18. PMID: 21376233.


Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y. CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell. 2008. Dec 5; 32(5): 718-26. PMID: 19061646.


Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. SCFβTRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature. 2008. Mar 20; 452(7185): 370-4. PMID: 18354483.


Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J. 2007. Oct 31; 26(21):4523-34. PMID: 17932490.

 


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